PdA relevant publications on inflammation, cancer and aging

1/       Oxidative stress and inflammatory disease

Antioxidant and anti-inflammatory protection of vascular endothelial cells by synthetic mimics of glutathione peroxidase. J.Chaudière, M.Moutet et P. d'Alessio - C.R. Soc. Biol., 1996, 189 : 861-882

Pharmacological modulation of endothelial cytoskeleton induced by hydrogen peroxide and TNF-α. P. d'Alessio, M.Moutet, C.Marsac  et J.Chaudière - C.R. Soc. Biol., 1996, 190 : 289-297

ICAM-1 and VCAM-1 expression induced by TNF-α are inhibited by a glutathione peroxidase mimic. P.d'Alessio, M.Moutet, S.Darquenne, E. Coudrier and J.Chaudière. Free Rad.Biol.Med., vol. 24, No. 6, 1998, pp 979-987

GPx mimics prevent TNF-α and neutrophil-induced endothelial alterations. M.Moutet, P.d'Alessio, P.Malette, and J.Chaudière. Free Rad.Biol.Med., vol. 25, No. 3, 1998, pp 270-281

ICAM-1 and VCAM-1 expression induced by TNF-α are inhibited by a glutathione peroxidase mimic. P.D'Alessio, M.Moutet, S.Darquenne, E.Coudrier and J.Chaudière ; in : “ Vascular Endothelium : Mechanisms of Cell Signaling ” J.D.Catravas, A.D.Callow, U.S.Ryan ed.s, Nato Science Series IOS Press, 1999, pp 220-225

2/       Role of Nitric Oxide in inflammation

Regulation of ICAM-1/CD54 expression on human endothelial cells by hydrogen peroxide involves inducible NO synthase. M. Sadeghi Zadeh, J.-P. Kolb, D. Geromin, R. D’Anna, A. Boulmerka, A. Marconi, B. Dugas, C. Marsac and P. d'Alessio – Journal of Leukocyte Biology, Vol.67, March 2000, 327-334

Naftidrofuryl-driven regulation of endothelial ICAM-1 involves Nitric Oxide. A. Marconi, S. Darquenne, A. Boulmerka, M. Mosnier, P. d’Alessio, Free Rad.Biol.Med., Vol 34, No 5, 2003, 616-625.

3/       Vascular endothelium and cancer (HPV-16 E7)

HPV16-E7 but not E6 oncogenic protein triggers both cellular immunosuppression and angiogenic processes. H. LeBuanec, R.D’Anna, A. Lachgar, J.F.Zagury, J.Bernard, D.Ittelé, P.d’Alessio, S. Hallez, C. Giannouli, A.Burny, B.Bizzini, R.C.Gallo, D.Zagury – Biomed.&Pharmacother. 1999, 53: 424-431

Human Papillomavirus-16-E7 Oncoprotein Enhances the Expression of Adhesion Molecules in Cervical Endothelial Cells but not in Human Umbilical Vein Endothelial Cells. R.D’Anna, H. Le Buanec, B. Bizzini, A. Burny, C. Giannouli, J.F. Zagury, R.C. Gallo, D.Zagury and P.d’Alessio -  Journal of Human Virology, Vol 4, No. 2, 2001, 85-95.

Selective activation of cervical microvascular endothelial cells by human papillomavirus 16-E7 oncoprotein. R.D’Anna, H. Le Buanec, G. Alessandri, A. Caruso, A. Burny, R. Gallo, J.F. Zagury, D.Zagury, and P.d’Alessio, Journal of National Cancer Institute, Vol 93, No. 24, 2001, 1843-1851

4/       Characterization of inflammatory mechanisms in aging

Skin ageing: The Relevance of Antioxydants. P.Giacomoni and P.d'Alessio; In: “ Molecular Gerontology ” Suresh I.S.Rattan and Olivier Toussaint ed.s, 1996, pp 177-192

Photoageing of the skin. P.Giacomoni and P.d'Alessio;  In: Open questions in photobiology IV. Photoaging of the skin J. Photochem. Photobiol. B:Biol., 1996, 33 : 267-272

Skin aging: Mechanisms and Possible Interventions. P.Giacomoni and P.d'Alessio; In: Advances in Anti-Aging Medecine, vol. 2, Academy of Anti-Aging Medecine ed.s, 1997
Aging and the endothelium. P. d’Alessio, 2004, Journal of Experimental Gerontology, 39(2):165-171.

5/       Endothelium as pharmacological and therapeutical target

Pharmacological inhibition of endothelial cytoskeleton alterations induced by hydrogen peroxide and TNF-α P.D'Alessio, M.Moutet, C.Marsac and J.Chaudière; in: “ Oxidative Stress, Cancer, AIDS, and Neurodegenerative Diseases ”. Marcel Dekker, Inc., N.Y., Montagnier, Olivier, and Pasquier ed.s, 1997, pp 313-321

Endothelium as pharmacological target. P. d’Alessio, Curr. Op. Invest. Drugs, Vol 2, No. 12, 2002, 1720-1724.

Antioxidant Betalains from Cactus Pear (Opuntia Ficus Indica) inhibit endothelial ICAM-1 expression. C. Gentile, L. Tesoriere, M. Allegra, M.A. Livrea. Annals and P. d’Alessio, Annals NYAcadSci, 2004, vol.1028, "Signal Transduction and Communication in Cancer Cells", pp 481-486

Tripterine inhibits the expression of adhesion molecules in activated endothelial cells Deng-hai Zhang, Anthony Marconi, Li-Min Xu, Chun-xin Yang, Guo-wu Sun, Xiao-ling Feng, Shu-min Xu, Chang-quan Ling, Wan-zhang Qin, Georges Uzan and Patrizia d’Alessio, Journ Leuko Biol, 2006, vol 80, pp 309-319.

Fasciatherapy combined with Pulsology induces changes in blood turbulence potentially beneficial for the Endothelium Queré N,Noël E, Lieutaud A, d'Alessio P. JBMT, J Bodyw Mov Ther. 2009 13(3) : 239-45, Epub 2008 Aug 12

Anti-Inflammatory Senescence Actives 5203-L Molecule to Promote Healthy Aging and Prolongation of Lifespan. J.-F. Bisson, C. Menut and P. d’Alessio  Rejuvenation Research, 2008, Vol. 11, No. 2: 399-407

New Anti-Inflammatory Molecule AISA 5203-L promotes adaptive strategies in cell aging. P. d’Alessio in : Adaptation Biology and Medicine, Cell Adaptations and Challenges, ed.s P. Wang, C.-H.Kuo, N. Takeda and P.K. Singal, Narosa Publishing House Ltd., 2011, Vol. 6, 369-378.

New Targets for the Identification of an Anti-Inflammatory Anti-Senescence Activity. Patrizia d’Alessio, Annelise Bennaceur-Griscelli, Rita Ostan and Claudio Franceschi, 2012.

Gender differences in response to dietary supplementation by Orange Peel Extract in elderly people in the RISTOMED study: impact on Quality of Life and inflammation. d’Alessio P., Ostan R., Valentini L., Bourdel-Marchasson I., Pinto A., Buccolini F., Franceschi C., Bené M.C. PRIME July/August, 30-37, 2012.

Cellularité & Extracellularité. in : "Entrée en Matière Vivante" Annales Société Française Chirurgie Plastique, Reconstructrice et Esthétique, L. Andrac, P. d’Alessio, D. Casanova, J. Chaline, J.-C. Dardour, J.-P. Delage, C. della Volpe, J.-C. Guimberteau, A.-I. Kapandji, R. Legré, G. Magalon editors, Plastique, Reconstructrice et Esthétique, Elsevier, 57: 497-501, 2012.

On the way of Longevity: how to counteract neurodegenerative disease » P. d’Alessio, Rita Ostan, Miriam Capri, Claudio Franceschi, in : Senescence and senescence – related disorders, Edited by Zhiwei Wang & Hiroyuki Inuzuka, INTECH, 2013.

Oral administration of d-Limonene controls inflammation in rat colitis and displays anti-inflammatory properties as diet supplementation in humans. Patrizia A. d'Alessio, Rita Ostan, Jean-François Bisson, Joerg D. Schulzke, Matilde V. Ursini, Marie C Béne, Life Sciences, 92 1151-56, 2013.

Skin repair properties of Perillyl Alcohol in murine models. Patrizia A. d'Alessio, Massoud Mirshahi, Jean-François Bisson, Marie C Béné, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, (1):29-35, 2014.

Anti-stress effects of d-Limonene and its metabolite perillyl alcohol. Patrizia A. d'Alessio, Jean-François Bisson, Marie C Béné. Rejuvenation Research, (2):145-9, 2014.

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